*Twelve-week, single-center, clinical study was conducted on 81 females, ages 35 to 65, Fitzpatrick I-VI with mild to moderate skin softness, firmness, and elasticity on the cheeks, as well as fine lines, wrinkles, skin smoothness, plumpness, lifting, skin-tone evenness, radiance, and overall appearance of skin condition on the global face, and including some who have crow's-feet wrinkles, undereye wrinkles, perioral wrinkles, forehead lines, marionette lines, and the appearance of nasolabial folds. Product was applied twice daily in conjunction with use of regular cleanser, moisturizer, and sunscreen. Efficacy evaluation conducted at baseline, post-application, and at weeks 1, 4, 8, and 12.